300848 Metabolism - Metabolic Disorder and Metabolic Manipulator Report Writing - Biology Assignment Help

300848 Metabolism Metabolic Disorder and Metabolic Manipulator Report Writing Assignment Help

Assignment Task:

1. Overview
Identify the name(s), class and structure of the ‘Metabolic Disorder’ (Report Part A) and ‘Metabolic Manipulator’ (Report Part B) molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Disorder (Part A) and Manipulator (Part B) has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Disorder (Part A) and Manipulator (Part B) (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, half-life, receptor
activation and fate following action - Disorder (Part A) effect, and Manipulator (Part B) degradation within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Disorder Part A) and Manipulator (Part B) alters, including key enzymes/cofactors and intermediates directly affected.

• Contextualize & Crystalize – identify broad nature of disorder and focus on major element.

• In one paragraph! – Consider multiple paragraphs for each topic (and subheadings).

• Address each element identified under the heading of Overview.

• Link to metabolic pathway affecting Lipids, CHO’s or AA’s?
o Need to target disruption to metabolism as consequence of disorder

• Relevant schematics/figs/diags/tables – only use them if you comment on them in the body of text.

• Labelling & referencing – all clearly and appropriately!

• Identify acronyms, colours or symbols used in figs etc and their relevance

• Analysis method of disorder needs to be identified (details in Diagnosis).

2. Research
Describe the most recent research (published scientific article(s)) effort pertaining to the Disorder (Part A) and Manipulator (Part B). This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s).

• Old (>70’s when current available)

• Limit books & websites as refs.

• Cite primary refs not just reviews.

• Need to discuss relevance of research – do not just list research papers etc!

3. Diagnosis
Identify the disease state(s)/or consequence(s) of the Disorder (Part A) and Manipulator (Part B) that arise if there is a genetic defect (Part A) or chemical perturbation (Part B) in the metabolic/biosynthetic pathway of target cells/tissues.

• Details of current diagnostic(s) (analysis method).
o Includes flow diagram of working through differential diagnosis and assay selection.

• Discuss afflicted Population stats (should be under this heading).
o Prevalence – local, national and global!
Identify the disease state(s)/or consequence(s) of the Disorder (Part A) and Manipulator (Part B) that arise if there is a genetic defect (Part A) or chemical perturbation (Part B) in the metabolic/biosynthetic pathway of target cells/tissues.

• Details of current diagnostic(s) (analysis method).
o Includes flow diagram of working through differential diagnosis and assay selection.

• Discuss afflicted Population stats (should be under this heading).
o Prevalence – local, national and global!

4. Treatment
Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder (Part A) and Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment.

• Need critical analysis – how does the treatment work/mechanism of action?

• Should include relevant Dose(s)/Time-course(s), efficacy, ‘Cocktail Therapies’
o Include target patient(s) – young/old/male/female (or exclusions)
o Adverse Events
o Potential for new treatment options eg Gene Therapy

• Need to discuss relevance/outcome on CHO, AA & Lipids

• Elaborate prognosis i.e. quality of life, life expectancy, long term effects of treatment.

• Patient compliance!

5. Policy
Outline the current policies/legislation (federal, state or international) relevant to the Disorder (Part A) and Manipulator (Part B) (e.g. adverse health outcomes or legislation for therapeutic use).

• Related/relevant link policies e.g.:
o clinician reporting requirements,
o treatment application (oral, nasal, injection).

4. Treatment
Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder (Part A) and Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment.

• Need critical analysis – how does the treatment work/mechanism of action?

• Should include relevant Dose(s)/Time-course(s), efficacy, ‘Cocktail Therapies’
o Include target patient(s) – young/old/male/female (or exclusions)
o Adverse Events
o Potential for new treatment options eg Gene Therapy

• Need to discuss relevance/outcome on CHO, AA & Lipids

• Elaborate prognosis i.e. quality of life, life expectancy, long term effects of treatment.

• Patient compliance!

5. Policy
Outline the current policies/legislation (federal, state or international) relevant to the Disorder (Part A) and Manipulator (Part B) (e.g. adverse health outcomes or legislation for therapeutic use).

• Related/relevant link policies e.g.:
o clinician reporting requirements,
o treatment application (oral, nasal, injection).

Report Part B -

Metabolic Manipulators Biochemical Analysis of cells, tissue, blood and urine is important in the detection of disease, organ failure, doping/drug cheating in forensic investigations,a nd sports (human or animal). This Report will enable you to relate your lecture and laboratory experience to real world biochemical analysis.

- Research will address the current research, published in scienti?c journals, regarding the topic or condition.

- Diagnosis will address the current diagnostics applied to the topic or condition.

- Treatment will address the current treatment options relevant to the topic or condition.

- Policy will address the current policies/legislation (federal, state or international) relevant to the topic or condition (e.g. adverse health outcomes or legislation for drug use).

1. Overview Identify the name(s), relevant EC number, class and/or structure of the ’Metabolic Disorder’ (Report Part A) and ’Metabolic Manipulator’ (Report Part B) molecule and contextualize the intracellular metabolic biochemical pathways they a?ect (i.e. Protein, Carbohydrate, Lipid &/or Oxidative Phosphorylation). Brie?y outline the e?ect(s) the Disorder (Part A) and Manipulator (Part B) has on the organism locally (i.e. speci?c cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical/chemical synhesis steps to producetheDisorder(PartA)andManipulator(PartB)(i.eparentand/oractivemolecule,keyenzymes&cofactors involved in the disorder) and describe the relevant transport, half-life, receptor activation and fate following action Disorder (Part A) e?ect, and Manipulator (Part B) degradation within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate, Lipid &/or Oxidative Phosphorylation), the selected Disorder (Part A) and Manipulator (Part B) alters, including key enzymes/cofactors and intermediates directly a?ected.

2. 2. Research Describe the most recent research (published scienti?c article(s)) e?ort pertaining to the Disorder (Part A) and Manipulator (Part B). This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identi?cation of potential therapeutic(s).

3. 3. Diagnosis Identify the disease state(s)/or consequence(s) of the Disorder (Part A) and Manipulator (Part B) that arise if there is a genetic defect (Part A) or chemical perturbation (Part B) in the metabolic/biosynthetic pathway of target cells/tissues.

 4. Treatment Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder (Part A) and Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment.

5. Policy Outline the current and/or relevant policies/legislation (federal, state or international) pertinent to the Disorder (Part A) and Manipulator (Part B) (e.g. adverse
health outcomes or legislation for therapeutic use).

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