4PHYM002W: Fundamentals of Pharmacology - Investigation of A Possible Aspiration Oversose Essay Writing - Nursing Assignment Help

Assignment Task

    
Part A

Our investigator has noted colour changes of various kinds, following mixing aliquots of patient samples with Trinder’s Reagent (TR).

The following three questions refer to the laboratory investigation. 

(1) TR is used to assay salicylate and not aspirin (acetylsalicylic acid). Choose ONE response that correctly states why this is important:

• Salicylate is the main active metabolite of aspirin, so establishing its presence in patient samples is more significant from a clinical perspective;
• Salicylate is only detectable in samples taken from patients with severe inflammatory conditions;
• Salicylate is the only drug available for treating irritation of the stomach mucosa (gastritis), so it’s crucial that it can be detected in stomach contents.
• In this case, the patient obviously possesses a genetic trait which means they will convert all of an aspirin dose to salicylate rapidly.

Required
(2) When the patient serum sample was mixed with TR, a precipitate was formed.
Choose the explanation that best explains this observation:

• TR provides a strongly alkaline environment, causing all macromolecules
• (including proteins) to form a precipitate;
• TR forms of a precipitate with proteins, due to the presence of Cu 2+ and Fe2+
• ions. This reaction is only able to occur in a neutral pH environment;
• TR provides a strongly acidic environment, thereby causing the precipitation of
• proteins;
• The pH of TR has no bearing upon the formation of precipitate, and this was due
• to the presence of another chemical component of the reagent.

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