Amount of Serotonin in the Blood Falls Sharply at the Onset of Migraine Nursing Assignment Help

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The chemistry of migraine, however, seems to have some connection with the nerve hormone named serotonin, which is naturally present in the brain. The amount of serotonin in the blood falls sharply at the onset of migraine, and one migraine drug. methyser-gide, or Sansert, seems to have some effect on scro-tonin. Methysergide is a derivative of lysergic acid (in fact Sandoz Pharmaceuticals first synthesized LSD-25 while looking for a migraine cure), and its use is hemmed about with so many contraindications and side effects that most doctors prescribe it only in the most incapacitating cases. Methysergide, when it is prescribed, is taken daily, as a preventive; another pre-ventive which works for some people is old-fashioned ergotamine tartrate, which helps to constrict the swell-ing blood vessels during the "aura," the period which in most cases precedes the actual headache. Once an attack is under way, however, no drug touches it. Migraine gives some people mild hallucina-tions, temporarily blinds others, shows up not only as a headache but as a gastrointestinal disturbance, a painful sensitivity to all sensory stimuli, an abrupt overpowering fatigue, a strokelike aphasia, and a crip-pling inability to make even the most routine connec-tions. When I am in a migraine aura (for some people the aura lasts fifteen minutes, for others several hours), I will drive through red lights, lose the house keys, spill whatever I am holding. lose the ability to focus my eyes or frame coherent sentences, and generally give the ap-pearance of being on drugs. or drunk.
 

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