BE919 - Drug-Eluting Stent Development and Assessment - Medical Science Assignment Help

Assignment Task

Raw Data: Please see file uploaded onto MyPlace entitled, ‘Drug-eluting stent project data’. This file contain the three worksheets (Roughness, Endothelial Cells, Drug Release), each corresponding to different parts of the study.

Background: Coronary stents are widely used in the treatment of coronary heart disease. The most advanced of these devices are drug-eluting, meaning that a drug is gradually released from the stent surface into the artery wall for a sustained period, with deliver over a 28 day period found to be effective. This drug release helps ensure that the vessel lumen stays open, thereby improving the effectiveness of these devices, but there is still an opportunity to develop even better drug-eluting stents (DES) and much research is dedicated towards this. In particular, intense research is underway to develop DES that promote the proliferation of endothelial cells on the surface of the stent.

Methodology: In this study, the performance of three different coronary stent types was examined. The stents wwre subjected to one of three surface treatments to induce different levels of roughness: electropolishing (stent A), coarse grain sand-blasting (stent B) and fine grain sand-blasting (stent C). In the first part of the study, the roughness of each different stent type was measured using Atomic Force Microscopy (n=5). In a second series of experiments using the same stents, endothelial cells were seeded onto the stentsurfaces and incubated under standard cell culture conditions, with the number of cells present on the surface being counted after 7 days (n=5). In the final part of the study, a fresh batch (n=3) of each surface treated stent was coated with 100 ?g of the antiproliferative drug, Biolimus. The coated stents were then incubated in physiological solution (maintained at 37 ?C) and the in vitro drug release from the surface quantified at different time points up to 28 days.

Key research questions to be addressed:

1. How effective are the surface treatments at inducing different levels of roughness on the stent surfaces?

2. How does the stent surface roughness impact upon: a endothelial cell proliferation? b drug release kinetics?

3. Which one of the different stent types would you recommend taking forward for further development?

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