Bioinformatics & Gene Micro-Arrays - Nursing Assignment Help

Assignment Task

Task
1. (i.) Gene microarray systems comprise either “one colour” or “spotted” arrays. State which of these approaches can be used to study two samples simultaneously on the same microarray (1 mark). What readout results from this array approach? 
(ii.) Explain what is meant by the term “probeset” (Column 4 in the Table) in the one-colour microarray procedure.  

(iii.) Use the open-access resource GeneCards (https://www.genecards.org/) to determine the three missing gene descriptions in Column 9 of the Table. 
(iv.) The researchers used biological triplicate samples from each of the two cancer cell lines to generate the mean intensity data for the Table (Columns 1, 2). How does a biologi
(v.) What Quality Control (QC) step can be performed to view such triplicate array data in order to check it is of a good enough standard for differential expression analysis? (1 mark) (vi.) State the two processes that are used to correct microarray raw intensity data in order to eliminate non-biological differences (such as brightness bias or spatial bias) between microarrays and to allow graphical display of non-skewed expression data within a manageable scale.  (vii.) Using their microarray intensity data the researchers obtained the list of genes in the Table that were differentially-expressed between the two cell lines by using a statistical test to generate a p value for every gene, as well as by analysing their fold increase.

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