BIOL2050: Character Transmission in Drosophila Melanogaster - Science Assignment Help

Assignment Task

The aim of this simulation is to learn as much as possible about the genetic inheritance of the three mutant characters: cross-veinless wings, forked bristles and yellow body in D. melanogaster.

Question 1: Indicate whether to cross (i) mutant females with wild-type males, or (ii) mutant males with wild-type females, or (iii) both (i.e. reciprocal crosses), to produce an F1 generation that will enable you to determine if the traits are dominant or recessive, and if they are sex-linked (on the X chromosome). Draw mating diagrams and Punnett squares to support your answer.

Question 2: Conduct the appropriate cross(es) using Drosophila Lab, record your F1 results and indicate whether the three mutant genes are: (i) recessive or dominant and, (ii) carried on the autosomes or sex-linked?

Question 3: To determine whether the mutant genes are independent or linked, a testcross is more appropriate than using data from the F2 generation. Knowing which are the recessive genes, indicate which individuals you would mate in this testcross. Draw a mating diagram & use the forked line method to predict the outcome of this cross.

Question 4: Conduct the appropriate testcross using Drosophila Lab, record your results and indicate whether the three mutant genes are inherited independently or whether they are linked? Include a chi square analysis to support your conclusion.

Question 5: If you conclude the genes are linked, (i) use your data to work out the gene sequence on the chromosome. (ii) Sketch a genetic map indicating the relative loci for each of these three alleles, and indicate the approximate map distance between each locus.
(iii) Calculate if there was any interference and indicate the significance of this result. Show your workings for the map distance and interference calculations.

Question 6 - How do your results compare to previously published data on the inheritance of the three mutant characteristics? Account for any differences you have
observed. Note: Your answer to this question should be a detailed discussion, with references to previously published literature. Remember to consider your findings from Q1-5 regarding the inheritance of these 3 genes.

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