BTEC2230 - Protein Structure Visualization - Science Assignment Help

Assignment Task

This assignment aims to give you an appreciation of the structural elements that constitute a protein drug target, to develop an understanding of the molecular interactions that result in the non-covalent binding of a small molecule to a protein, and to help you understand the basic concept of how ligand binding to a receptor results in a specific biological response.

You will use molecular graphics software (Cn3D) freely available at the NCBI website. Follow the instructions provided in the Instructions document to obtain this software, prepare the figures and source the information required for part one of this assignment.

Part two of this assignment requires you to interpret the biological data provided for potential inhibitors of Abl kinase.

Fill in the General Data for each structure:

Protein Structure 1:

1. PDB file code:

2. Title of structure:

3. Molecule 1 (receptor identity):

4. Number of Chains:

5. Organism:

6. Reference (write full reference of paper, J. Cell Sci. style):

7. Molecule 2 (small molecule ligand):

Protein Structure 2:

1. PDB file code:

2. Title of structure:

3. Molecule 1 (receptor identity):

4. Number of Chains:

5. Organism:

6. Reference (write full reference of paper, J. Cell Sci. style):

7. Molecule 2 (small molecule ligand):

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