CLTR5002 - Clinical Trial Research Report Writing - Nursing Assignment Help

Assignment Task:

TASK:

This assessment tasks requires you to prepare a 500 word methodological appraisal on each of two published research articles. Be sure to critique, and not simply paraphrase, the content of each article. Structure each appraisal in three parts so that it addresses the following points:

a) Study objectives, design, and conduct

Evaluate the suitability of the study to address the stated objective(s). What are the key strengths and limitations of the study design? The following issues may be of relevance in crafting your response: formulation of statistical hypotheses, comparator, assumptions underpinning the design, choice/construction/assessment of endpoints, trial phase, generalisability, sources of bias, interim monitoring, etc.

Explain the methodological concepts/issues of relevance for evaluating the implications of any deviations from / changes to the original research plan that arose over the conduct of the study. The following issues may be of relevance in crafting your response: accrual issues, treatment adherence issues, sources of bias, changes to endpoints/eligibility/interventions, etc.
 

b) Analysis methods

What is your assessment of the planned analysis approaches? Justify your perspective by highlighting and explaining the relevant methodological/analysis issues. The following issues may be of relevance in crafting your response: clarity of description of methods used, analysis set composition, stratification/adjustment, comparability of treatment groups at baseline, multiplicity, subgroup analyses, interim analysis / early stopping, missing data, presentation of results, etc.
 

c) Results and Conclusions

What do you think the key conclusion(s) should be? Describe any concerns/issues you perceive with the authors’ interpretation of the study results and their implications.

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