Complex Neurodegenerative Diseases Disorder - Medical Science Assignment Help

Assignment Task

Title of the propoanl:

Cumulative role of csic-3p and PARK genes pathway causing mitochondria! dysfunction in Parkinson's disease along with determination of Epigenetic factors involving in the pathogenesis of the disease. 
 

Objectives:

1. To identify the role PINK1 and Parkin and their interaction with GSK-30 and PA. genes causAg mitochondria! dysfunction in PD.

2. To identify the epigenetic factors In the pathogenesis of PD.

3. To identify the genetic polymorphisms. 
 

introduction: 

• Parkinson's d.ase is a complex neurodegenerative disorder for which both rare and common genetic variants contribute to disease risk, onset, and progression.

• Mutations in more than 20 genes have been associated with the disease, most of which are highly penetrant and often cause early onset or atypical symptoms.

• Although our understanding of the genetic basis of Parkinson's disease has advanced considerably, much remains to be done.

• Further disease-related common genetic variability remains to be identified and the work A identifying rare risk alleles has only just begun.

• To date. genome-wide association studies have identified 90 independent risk-associated variants. Hovvever, most of them have been identified in patients A European ancestry and we know relatively little of the genetics of Parkinson's disease in other populations.

• We have a limited understanding of the biological functions of the risk alleles that have been identified, although Parkinson's disease risk variants appear to be in close proximity to known Parkinson's disease genes and lysosomal-related genes.

• In the past decade, multiple efforts have been made to kwestigate the genetic architecture A Parkinson's disease. and emerging technologies, such as machine learning. single-cell RNA sequencing, and high-throughput screens, will improve our understanding of genetic risk. 
 

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