Control of Respiration Measuring Lung Volumes and Capacities - Medical Science Assignment Help

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Assignment Task:

Task:

Part 1 – Measuring lung volumes and capacities

Part 2 - Effect of dead space on alveolar ventilation Learning objectives

• measure respiratory volumes using a spirometer • describe the various lung volumes, capacities and rates and understand how they are used to diagnose disease

• describe the various factors which influence respiration rate

• describe the mechanisms by which PO2, PCO2 and pH regulate respiration

• explain the changes in lung function tests that occur in obstructive and restrictive disorders In this laboratory, you will be conducting a number of measurements of respiratory parameters, using each other as volunteer subjects. Students will be organised into groups of 3.

You are not required to participate as a subject if you do not wish to. The experiments will be conducted using the Powerlab recording system. Detailed instructions are provided below. You will use the overall class results to write up a full lab report (20% of total subject mark). 47 | Page Respiratory Airflow & Volume Written by staff of ADInstruments with modifications to methods and data collection. Background Gas exchange between air and blood occurs in the alveolar air sacs. The efficiency of gas exchange is dependent on ventilation. Cyclical breathing movements alternately inflate and deflate the alveolar air sacs (Figure 1). Inspiration provides the alveoli with some fresh atmospheric air, and expiration removes some of the stale air, which has reduced oxygen and increased carbon dioxide concentrations. Figure 1.

Basic Lung Anatomy Spirometry is becoming more important as respiratory diseases are increasing worldwide. Spirometry is the method of choice for a fast and reliable screening of patients suspected of having Chronic Obstructive Pulmonary Disease (COPD). COPD is the 12th leading cause of death worldwide and the 5th leading cause in Western countries. Studies suggest COPD could climb to be the 3rd leading killer by 2020. Most COPD cases are completely avoidable as 85-90% of cases are caused by tobacco smoking. Asthma is another respiratory disease and can be confused with COPD. People with asthma can experience a shortness of breath (dyspnea), wheezing, coughing, and tightness in their chest. In these people, the bronchi are always red and inflamed, even when they are not suffering an asthma attack. During an attack, the airways constrict and become filled with mucus. This can make physical activity difficult. Many important aspects of lung function can be determined by measuring airflow and the corresponding changes in lung volume. In the past, this was commonly done by breathing into a bell spirometer, in which the level of a floating bell tank gave a measure of changes in lung volume. Flow, F, was then calculated from the slope (rate of change) of the volume, V: F = dV dt More conveniently, airflow can be measured directly with a pneumotachometer (from Greek roots meaning “breath speed measuring device”)

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