Critical Appraisal of Non-Communicable Disease Etiology - Hypothesised Etiological Mechanism - Epidemiology Assignment Writing Help

Epidemiology Assignment Writing Help

Critical appraisal of non-communicable disease etiology

Task

The overall objective for this assignment is to select a journal article relating to a non-communicable disease outcome in order to summarise the putative aetiological mechanism of the outcome, assess the evidence-base for the association, and to consider methodological limitations in the interpretation of the association.

Select a peer-reviewed journal article that illustrates the critical period model, sensitive period model, or accumulation of risk model for an association between an exposure and a non-communicable disease outcome. Once you have selected an appropriate article, complete the following questions based on the article:

Question 1

Provide the reference of the article and indicate the following:

• The life-course model illustrated, and the period in the life-course to which the exposure relates

• Summarise the hypothesized aetiological mechanism by which the exposure is associated with the outcome

• Summarise the findings of the example article you selected

Question 2

Summarise the evidence-base that supports (or does not support) the association in the article you selected

Consider the following for this question:

• How many studies of the association?

• What type of studies? Based on what samples.

• Are findings across these studies consistent and coherent, particularly from studies of similar or more powerful study designs?

• Are the results plausible in terms of a biological mechanism?

Question 3

Consider the following for this question:

• Is there a temporal relationship between exposure and outcome?

• Is there a strong relationship between the exposure and the outcome?

• Is there a dose-response relationship between exposure and the outcome?

• Title Page Separator Site title Is the outcome measure affected by selection and/or measurement bias?

• Is the exposure measure affected by selection and/or measurement bias?

• Are the results likely to be affected by confounding?

• Are the results likely to be affected by chance variation?

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