Highlights
Case study:
Blood samples were taken from the children, which provided the evidence that indeed plasma cholinesterase activity was significantly reduced (plasma/red blood cell cholinesterase assay). Forensic testing on the water and cooking oil were analysed and “very toxic levels” of monocrotophos (https://en.wikipedia.org/wiki/Monocrotophos) an agricultural pesticide were detected.
But how did the monocrotophos come to contaminate the cooking oil? The local grocer had decanted the oil into containers that had previously contained insecticide,
but quite how this mix-up occurred was never firmly established. The grocer was charged with murder.
Question:
In general, how long do the effects of organophosphates last and how long to they persist in the body? Explain with respect to their pharmacodynamic and pharmacokinetic properties.
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