EGH418 - Biomechanics - Collagen Nano Mechanics - Engineering Assignment Help

Assignment Task

Learning Objectives
This laboratory aims to expand students’ knowledge on the mechanics of collagen, which underpins the function of tissues such as cartilage, tendon, ligament and bone. A secondary aim is to expose students to the approaches by which the knowledge base in the field is developed and advanced.
We aim to achieve this by taking part in a real experimental study. The data you will gather and analyse will form the basis of a journal paper contributing new knowledge to the field of biomechanics. Using samples of tendon (type I collagen), it will explore the use of advanced mechanical techniques to understand the structure-property-function relationships in one of the key building blocks of our bodies, and provide new insights into the contribution of nanometre and micrometre-scale mechanics to bulk tissue performance.

Collagen and the cartilage surface
Here, we will examine the collagen in a porcine tendon. Collagen has a fascinating hierarchical structure, which underpins its role as the highperformance, multifunctional building block of our bodies, and those of all mammals. As such, its function is central to materials-based strategies for regenerative medicine, as well as providing a biomimetic target for highperformance, multifunctional fibre-based materials in applications outside of biomedicine. The defining feature of collagen is an elegant structural motif in which three left-handed alpha chains coil with a one-residue stagger to form a right-handed triple helix, known as tropocollagen. Tropocollagen is unstable at body temperature, driving its formation into supertwisted, right-handed microfibrils with molecules packed in a quasi-hexagonal lattice.
This leads to a spiral-like structure within the mature collagen fibril, with interdigitated microfibrils forming a networked, nanoscale rope.
One interesting feature of collagen structure, which forms the focus of this investigation, is the banding patterns seen in the fibril, known as the gap and overlap regions. To gain access to these structures and decouple their mechanics, we will use scanning probe microscopy.

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