Highlights
"An experiment should be conducted for a particular reason. A statement which explains what the experiment is attempting to achieve is known as an aim. The prediction that the scientist make who is undertaking the experiment is known as the hypothesis”.
• The experiments you be carrying out are connected.
• In the lectures and online practical classes we have investigated how mutations in the coding sequence of a gene (exons) can change the amino acid sequence of a protein with an accompanying gain or loss of function.
• Coding sequencing mutations are common in cancer. However, coding sequences make up just a few percent of a genome, and the genome also includes several hundred thousand regulatory elements (promoters and enhancers) that control gene expression.
• In the era of whole-genome analyses , it is now understood that sequence changes in these regulatory elements can change gene expression with impacts on health and disease.
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