HBS204 - Advanced Systems Physiology B Endocrine Physiology Case Study, HPG Hormones - Physiology Assignment Help

Assignment Task

 Advanced Systems Physiology 

1. Draw a diagram of the HPG axis including the key hypothalamic, pituitary and gonadal  hormones involved as well as feedback loops?

2. Using the hormones that you have identified in your diagram (and also including leptin), complete the following table for each?

• Hormone 
• Type of hormone (peptide/lipid/amine)
• Transport  in the blood Receptor  
• location (cell  membrane  
• vs  
• intracellular) 
• 2nd 
• messenger pathway

3. What is the difference between the negative and positive feedback exerted by the gonadal  hormones, and how are the levels of the other HPG hormones affected in either case?
 

4. Leptin plays a permissive role in puberty. Explain what this means?

5. Given that leptin acts at the hypothalamus, how do you think it enhances reproductive  maturation and timing of puberty? 

6. Given the action of leptin and your understanding of hormone-receptor interactions, how do  you think this ratio changes when approaching puberty i.e. is it more free:bound hormone or  vice versa? Why do you think that this is the case? 

7. What would be the effect of a GnRH antagonist? How would this affect LH, FSH and gonadal  hormone levels when administered?

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