Heterogeneity of Toxicant Response: Sources of Human Variability

Assignment Task

A researcher conducted a cell toxicity study to compare the toxicity in different toxicants. He exposed the liver cell line with toxicant A, toxicant B, toxicant A together with toxicant B, and toxicant A together with toxicant C. After 24hours of exposure, he stopped the reaction and read the viability of the cell using an ELISA plate reader.

This is the outcome of his experiment:

Based on these outcomes,

1. Explain the dose-response relationship of all toxicants.

2. Which one is more potent? Toxicant A or B? Explain in 1 sentence.

3. What is happening in situation C and D? State your assumptions.

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