Mechanism of Action and Therapeutic Effect of Metronidazole - Medical Science Assignment Help

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Mechanism of action and therapeutic effect of metronidazole
Metronidazole is used for the bacterial infections along with protozoan infections (Bullock and Manias, 2017). It is active agai nst anaerobic bacteria only (Burchum and Rosenthal, 2019).
Upon administration of metronidazole, it affects the DNA and causes its breakage which results in the loss if DNA's helical shape (Burchum and Rosenthal, 2019). Metronidazole is considered bactericidal as it breakdowns the DNA and obstruct the replication of the bacterial cells (Bullock and Manias, 2017).
Metronidazole can be administered via IV or PO. As it is active against only the anaerobic organisms hence it does not harm persons healthy cells (Bullock and Manias, 2017). Metronidazole is used against the infections of CNS, abdominal organs, bones, joints, skin, soft tissues, and genitourinary tract. For the people with peptic ulcer disease, it is used with tetracycline and bismuth subsalicylate against Helicobacter pylori. It is also used in surgeries with high risk of infection for prophylaxis (Burchum and Rosenthal, 2019).

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