Metabolic Manipulator: Ammonium Chloride- Biochemical Analysis- Research Report Assignment

Internal Code: TV656

Research Report Assignment:

Task: My chosen metabolic manipulator is ammonium chloride. Each student will select a unique Disorder and Manipulator, from the list provided, addressing the current Research (R), Diagnosis (D), Treatment (T) and Policy (P) Part B (10%): ‘Metabolic Manipulators’ Assignment Part B – Metabolic Manipulators Biochemical Analysis of cells, tissue, blood and urine is important in the detection of disease, organ failure, doping/drug cheating in forensic investigations, and sports (human or animal). This assignment will enable you to relate your laboratory experience to real world biochemical analysis. You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided. Assignment (Part B), relates to lecture material conveyed in weeks 1-13, associated with disease(s) and/or medical condition(s). 1. Research will address the current research, published in scientific journals, regarding the topic or condition. 2. Diagnosis will address the current diagnostics applied to the topic or condition. 3. Treatment will address the current treatment options relevant to the topic or condition. 4. Policy will address the current policies/legislation (federal, state or international) relevant to the topic or condition (e.g. adverse health outcomes or legislation for drug use Criteria You will be assessed on the following: The Assignment must use the Headings below and address the following: 1. Overview Identify the name(s), class and structure of the ‘Metabolic Manipulator’ (Assignment Part B) molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Manipulator (Part B) has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Manipulator (Part B) (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, half-life, receptor activation and fate following action - Manipulator (Part B) degradation within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Manipulator (Part B) alters, including key enzymes/cofactors and intermediates directly affected. 2. Research Describe the most recent research (published scientific article(s)) effort pertaining to the Manipulator (Part B). This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s). 3. Diagnosis Identify the disease state(s)/or consequence(s) of the Manipulator (Part B) that arise if there is a chemical perturbation (Part B) in the metabolic /biosynthetic pathway of target cells/tissues. 4. Treatment Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Manipulator (Part B). Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment. 5. Policy Outline the current policies/legislation (federal, state or international) relevant to the Manipulator (Part B) (e.g. adverse health outcomes or legislation for therapeutic use). Report Format. Diagrams maybe used (with appropriate references). The report should be in 12pt font, ~1,000 words (for each Part A & Part B), with Vancouver referencing format (labelled as superscript numbers throughout the text and identified in the References, Website(s) should include accession dates). Note: References and diagram/legends are not included in the word count.