Highlights
Modeling Scientific Work
In this project you will: design your own scientific problem, convince everybody that the problem is of great interest, choose the experimental methods to address this question and explain why it is a right method to solve the problem. Also do, what scientists do to get their favorite research funded!
Write a report in which you: design a scientific question (suitable for one experiment or series of experiments) convince everybody that the question is interesting choose the experimental methods to address this question explain why it is a right method to solve the problem Techniques to use: NMR, Raman, DLS, X-ray (you may choose any other …) Be creative! This assignment will model the grant application which researcher are submitting to get their research founded For example: NMR
1) Choose a protein (real or imaginary) with some interesting function
2) Explain what you want to know: Structure (why? For example find the inhibitors, explain the function of protein)? Dynamics (why? may be changed by interaction with other proteins)?
3) Which NMR experiments you will do to get the assignment and then structure? (HNCA, HNCOCA, NOESY spectra ….) To get the information about dynamics (relaxation time measurements …)
4) Why use NMR and not x-ray crystallography (small protein, want to know dynamics ….)
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