Highlights
Main question: You are a general practitioner and are meeting with a 25yo male patient who has the mild-moderate major depressive disorder (MDD). He has had some relief from his symptoms from sertraline but has discontinued it (with your guidance) because the side effects were difficult to deal with. He is doing cognitive behavioural therapy (CBT) with a psychologist, and wants to supplement that with another medication, but is wary of antidepressants and their side effects. He has read about new advances in depression research and is interested in trying a treatment that targets inflammation, which he has read may be helpful. He would like to know if such treatments would work for him, and how they would work.
Sub-questions:
To help provide answers to your patient, address these questions and provide evidence (referenced journal articles) to back up your conclusions. Answer these questions in 2-3 pages, with an extra page allowed for your reference list.
Inflammation and Depression
Is inflammation involved in depression?
Can anti-inflammatory drugs be helpful for depression, are they ‘approved for use’ for depression treatment?
Can anti-inflammatory drugs be helpful specifically for mild depression?
What are the potential side effects of anti-inflammatory treatments?
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