Highlights
Assessment Case Study
Sarah, a 33-year-old woman who postponed pregnancy in her 20s has now been trying to get pregnant for several years. Her husband had a son during a prior marriage. She presents to her gynaecologist for work-up of her infertility. Relevant history includes menarche at age 12; four lifetime sexual partners; cyclic menses regularly every 30 days; no birth control for 2 years; no pelvic examination in 5 years. Sarah reports no intravenous drug use.
Vaginal examination findings include a friable, vascular lesion on the anterior uterine cervix, a cervical smear diagnosis of high-grade squamous intraepithelial lesion, a human papillomavirus (HPV) assay positive for high-risk HPV serotypes, and a cervical biopsy diagnosis of severe dysplasia (CIN III).
Please answer the following TWO questions: NUR241
1. Describe pathophysiology of cervical cancer. What risk factors can you identify in
Sarah’s case?
2. What are the latest guidelines for cervical screening in Australia? Provide scientific
rationale for these guidelines.
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