NURS12154 - Explain the Principles of Quality Use of Medicines (QUM) - Pharmacology Case Study - Nursing Assignment Help

Assignment Task

Learning outcomes:
1. explain the principles of quality use of medicines (QUM) relevant to nursing practice;
2. describe the pharmacodynamics and pharmacokinetics of particular drugs; and
4 demonstrate accountability in relation to safe administration of medications.

Instructions:
Assessment 1 consists of completing two (2) topics with questions linked to the case study.
Step 1: Read the case study. The link to this document is available under the ‘Assessment for this Unit’ tab; under ‘Assessment 1’.
Step 2: Use the case study, complete the two (2) topics listed below addressing the questions. You are required to attempt both two topics

Topics
Topic 1: Medication error 
There was a significant medication-related error that occurred, leading to a poor outcome for Damilola.
-Describe the medication-related error that occurred here and outline one (1) factor that contributed to the error.
-Refer to the NSQHS (2nd edition) Standard 4 - MedicationSafety. Choose one action 

from the NSQHS Standard 4 - Medication Safety list below and discuss how, as the nurse caring for Damilola, you would use this to prevent this type of medication error occurring again.

o Partnering with consumers: Action 4.3
o Adverse drug reactions: 4.7
o High-risk medicines: 4.15

Topic 2: Understanding Pharmacokinetics and Pharmacodynamics

The medical team at the hospital changed the antimicrobial to a broad-spectrum (ampicillin) for Damilola as part of the appendicitis treatment plan.

1. Discuss the pharmacokinetics (absorption, distribution, metabolism, excretion) of penicillins.

Include in your response:
a) Absorption:
• Clarify how penicillins can be absorbed, i.e. routes of administration.
• Explain the difference in the onset of action between administering penicillins via oral and intravenous routes.
• Discuss which is the most appropriate route to administer this antimicrobial to Mrs Anderson and provide an evidence-based rationale for your decision.
b) Distribution: After absorption, some of the penicillins, binds to plasma proteins.
• Discuss your understanding of ‘protein binding’.

c) Metabolism:
• Describe the half-life of penicillins
d) Excretion:
• Briefly discuss the organ responsible for the excretion of penicillins and the importance of monitoring its function.
• Identify the renal clearance of penicillins and your understanding of this phrase.
2. Discuss the pharmacodynamics (mechanism of action) of penicillins.
• Discuss how penicillins work to manifest its pharmacological effects.
• Discuss two (2) major side effects and/or adverse reactions of penicillins specifically relating these effects to Mrs Anderson.

Note: The word count is considered from the first word to the last word of each topic, excluding topic headings. Word length includes citations and direct quotations. It excludes the cover page, reference list and appendices (if applicable).

Format:
• Size 12 font size (Times New Roman)
• Double-line spacing
• 2.54 cm margins
• Page numbers, name and student number on each page

The following format is to be used to present your submission (include topic headings):

- First page: cover page
- Next page:
• Topic 1: Medication error
• Topic 2: Understanding pharmacokinetics and pharmacodynamics
- Last page: Reference list and if applicable, appendices.

Referencing Style: APA referencing 7th edition (available on the unit Moodle site under the 'Assessment' tab). Please note that referencing is worth 15% of your overall marks for this assessment item.

• The study guide, unit profile, and PowerPoint slides supplied on the unit Moodle site are not to be used as reference sources but are useful resources to guide your submission.

• Journal articles and other sources within five years old, and textbooks within 10 years old should be used.

Case Study for Assessment One Short Answer Topics

Damilola Anderson is a 62-year-old woman. She was travelling with her husband to see their children and grandchildren following Queensland’s eased COVID-19 restrictions. Damilola developed generalised abdominal pain, fever, and vomiting and was admitted to the CQUniversity Hospital (CQUH). After being assessed in the emergency department (ED), Damilola was diagnosed with acute appendicitis. A broad-spectrum antimicrobial, ceftriaxone was commenced immediately and she underwent a non-elective appendectomy. As part of the treatment plan, paracetamol is charted as regular analgesia, oxycodone as prn analgesia and ondansetron as a once only order for nausea/vomiting. Damilola has a history of severe anaphylaxis to penicillins.

On day 2 post-op care on a surgical ward, the medical team reviewed Damilola and ceased ceftriaxone. They commenced Damilola on ampicillin. Nurse B administered ampicillin as per the medication order and Damilola developed anaphylaxis. Nurse B activated a medical emergency team (MET) call and the MET moved Damilola to the intensive care unit for further care.

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