Palythine Significantly Absorbs in the UVB Region - Medical Science Assignment Help

Assignment Task:

Task:

Our second study done by Lawerence and collageues was interesting in demonstrating if palythine, a MAA, is protective against molecule photodamage on an in vitro model of human skin. They did this by extracting palythine from the red algae Chrondus yendoi, They used an immortalized human keratinocyte cell line (HaCaT. They diluted the extracted product to which in different concentrations with phosphate-buffered saline and ells were washed three times in PBS and covered with palythine dissolved in PBS (0–10%). The lid was removed and cells were then irradiated with either SSR or UVA radiation (5–20 J cm −2  or 20 J cm −2 , respectively). After irradiation, palythine solutions were removed and the cells washed a further three times and replaced in media or processed immediately depending on the experimental design. They measured cell viability 24 after irrdiation. This study investigated clinically relevant molecular biomarkers associated with solar UVR?induced damage to human skin
 

RESULTS SECOND STUDY
The study found that palythine significantly absorbs in the UVB region.  Inhibited induced cell death, protected againsdt UV radiation induced DNA damage, inhibited induced expression of genes encoding inflammatory cytokines, The data show that palythine protects against SSR?induced markers of inflammation, oxidatively generated stress and photoageing.

Strength

Limitation
 Results are only applicable to UVB spectrum. More research required on UVA exposure. 
 However, there may be some differences between HaCaTs and normal human keratinocytes or whole skin.
 

Significance 2
his suggests that MAAs have the potential to be developed as effective biocompatible UVR filters that may appeal to the public as natural products.
The data also suggest that MAAs may have a role in after?sun preparations.

Significance

•  Showcase the potential for high photoprotective properties to be implemented in sun protection products

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