Highlights
Task:
Instructions for Assessed Poster Presentation
You are required to research, prepare and present a poster on the enzyme that has been randomly allocated to you; this is in the list provided on Learn. You must submit an electronic version of your poster as a pdf file to the drop box on the Learn website NO LATER THAN:
Researching the topic:
You should start by obtaining background information about your enzyme from the enzyme databases and from textbooks. You will then need to extract more specific information from further reading of the primary literature. It is expected that in-depth information, with up-to-date and relevant examples will be drawn from wider reading and the databases. You will find that there is an abundance of material about your enzyme and you will need to be selective in what direction you research further, in order to avoid becoming overwhelmed by too much information. You are not expected to present every known fact about your enzyme, but your poster should cover key, well-established general information such as the enzyme class, function, mechanism, substrates and structure. If you follow this information by a focus on one, or a few, up-to-date biologically, biotechnologically or medically relevant issues, this should result in an interesting story for you to present.
STRUCTURE OF FUMARASE
Structure: It is an alpha protein belonging to the L-aspartase/fumarase family. It resembles a tetramer of identical subunits. The enzyme has two
dicarboxylate binding sites namely the A site and the B site (Weaver et al., 2019).
MECHANISM OF ACTION OF FUMARASE ENZYME
Fumarase hydration takes place in the seventh step of the TCA cycle
It converts fumarate to L-malate in the mitochondria
Cytosolic fumarase plays a role in the DNA damage response and double strand breaks
It is involved in the eukaryotic and prokaryotic DNA damage (Leshets, 2018).
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