Highlights
Abstract
Objective
To characterise the clinical features of children and young people admitted to hospital with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK and explore factors associated with admission to critical care, mortality, and development of multisystem inflammatory syndrome in children and adolescents temporarily related to coronavirus disease 2019 (COVID-19) (MIS-C).
What is already known on this topic
Less information on ethnicity, comorbidities, and clinical and laboratory findings is available in children with SARS-CoV-2 than in adults
A multisystem inflammatory syndrome in children and adolescents (MIS-C) temporally associated with SARS-CoV-2 has been widely reported However, all reports to date arise from retrospective cases series that are vulnerable to the ascertainment, selection, and recall bias
What this study adds
Severe disease was rare and death exceptionally rare in this is a large prospective cohort study of children admitted to hospital with laboratory-confirmed COVID-19
Ethnicity seems to be a factor in both critical care admission and MIS-C This cohort has enabled identification of additional clinical and laboratory characteristics that should help to refine the WHO criteria for MIS-C.
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