The Effect of the use of Thyme Honey Case Study - Management Assignment Help

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The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: A randomized controlled trial Melanie Charalambour", Vasilios Raftopoulosh, Lefkios Paikousist, Nicos Katodritisd, Ekaterini Lambrinoull, Dimitrios Vomvasd, Morpho Georgioud, Andreas Charalambousb • Educational Sector. Minutry of Health, Cyprus Cyprto University of Technology, Nunn Dfpart7/1014 CYMUS teat Pancousis Statistics, thythovau. Nthosth. ()Ma Bank of Cap-us OnroMgy Center, Cypnas 
ARTICLE INFO ABSTRACT 
FrvisowiLe Read and neck cancer Management money Radiation.induced mamma 

Purpose: Radiation-induced oral mucositls Is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. Methods: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria). and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later. Additionally, the Oral Mucositis Weekly Questionnaire (OMWQ) was given at 4th week of radiotherapy, 1 month after the completion of radiotherapy and 6 months later. The ClinicalTtials giw Identifier for this study is MC701466308. This paper reports on the findings regarding thyme honey's effectiveness on oral mucositis. Results: Generalized estimating equations revealed that patients in the intervention group were graded lower in the objective amassment of oral mucositis (p < 0,001), maintained their body weight (p < 0,001) and showed an improvement in their global health (p 0.001) compared to the control group. Quality of life of the patients in the same group was also statistically significantly higher than that of the patients of the control group (p < 0,001). conclusion.' The study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis and quality of life in head and neck cancer patients. 
 

1. Introduction 
Radiation-induced oral mucositis (OM) is the epithelial damage that may occur on oral, pharyngeal and laryngeal =CM, as a result of the ionizing radiation exposure mainly between the 2nd and 3rd week of conventional radiotherapy (Radvansky et al.. 2013). To this date, ra-diation-induced OM remains one of the most common side effects of radiotherapy In head and neck (H&N) cancer (Al Jaouni et al., 2017). OM can be of varying degrees, with more severe OM leading to mouth ulcers, painful dysphagia and consequently to poor quality of life (QoL), but also in discontinuance of the treatment (Mercadante et al., 2015). The duration of the symptoms normally extends over a -6-week period following the start of radiation therapy and resolve within 8 weeks after the completion of treatment (Bensinger et al., 2008). Its severity depends on several factors related to the diagnosis and 
treatment, the interval between the day of treatment, the radiation daily dose, previous exposure to chemotherapy, concomitant che-motherapy, the characteristics of the patient, oral hygiene and the ex-istence of co-morbidities (Mantel,. et al., 2016). The management of OM aims both to relieve the symptoms, but also to minimize any secondary complications (Shueng et al.. 2009). As part of a comprehensive management strategy for OM, head and neck cancer patients are taught by the health professionals to implement good oral care and hygiene measures, encouraged to use analgesics, and advised to take high-calorie foods with essential nutrients to speed-up the healing process (I lams et al., 2008). Furthermore, there are numerous pharmacological and non-phar-macological agents available for the treatment of OM (Kobya and Grithica. 2016). A number of these agents have been studied and used for OM locally with mixed results. These include sucralfate (Loprinzi 
 

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